Peptide-based anticancer vaccines
نویسندگان
چکیده
منابع مشابه
Peptide-based anticancer vaccines
Poorly biodegradable, incomplete Freund's adjuvant (IFA)-based anticancer vaccines primed CD8+ T cells that did not localize to the tumor site but to the persisting, antigen-rich vaccination site, which became a T-cell graveyard. Short-lived, water-based formulations and the provision of immunostimulatory molecules overcame this issue, resulting in tumor suppression. Here, we discuss the implic...
متن کاملTrial Watch: Peptide-based anticancer vaccines
Malignant cells express antigens that can be harnessed to elicit anticancer immune responses. One approach to achieve such goal consists in the administration of tumor-associated antigens (TAAs) or peptides thereof as recombinant proteins in the presence of adequate adjuvants. Throughout the past decade, peptide vaccines have been shown to mediate antineoplastic effects in various murine tumor ...
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Classically all vaccines were produced using live or attenuated microorganisms or parts of them. However, the use of whole organisms, their components or the biological process for vaccine production has several weaknesses. The presence of immunologically redundant biological components or biological impurities in such vaccines might cause major problems. All the disadvantageous of traditional ...
متن کاملPeptide-based tumor vaccines
Introduction Several specific tumor antigens have been defined by virtue of their immunogenicity in cancer patient5 [1,2]. In addition to the definition of specific tumor antigens, we now understand that T-cells recognize those antigens as peptides presented in the context of human major histocompatibility (MHC) molecules. These basic ob5ervatioJ15 have generated interest in the design of tumor...
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Vaccines optimize the presentation of an immunogen to the immune system, oftentimes enhancing or replacing the natural activators of antigen presenting cells in order to promote the delivery and the response of T and B lymphocytes to the immunogen. The purpose of this series is to describe new technologies which allow vaccine design, based on our understanding of the immune response, using diff...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2013
ISSN: 2162-402X
DOI: 10.4161/onci.24743